clinically unapparent infantile thiamin deficiency in vientiane, laos老挝万象,临床上不明显的婴儿维生素b1缺乏.pdfVIP

Clinically Unapparent Infantile Thiamin Deficiency in Vientiane, Laos 1,2 3 4 1,2 Sengmanivong Khounnorath , Karen Chamberlain , Ann M. Taylor , Douangdao Soukaloun , Mayfong Mayxay2,5, Sue J. Lee4,6, Bounthom Phengdy1,2, Khonsavanh Luangxay1,2, Kongkham Sisouk1,2, Bandit Soumphonphakdy1,2, Khaysy Latsavong1,2, Kongsin Akkhavong1,2, Nicholas J. White2,4,6, Paul N. Newton2,4* 1 Department of Pediatrics, Mahosot Hospital, Vientiane, Lao People’s Democratic Republic, 2 Wellcome Trust-Mahosot Hospital-Oxford Tropical Medicine Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People’s Democratic Republic, 3 MRC Human Nutrition Research, Cambridge, United Kingdom, 4 Centre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom, 5 Faculty of Postgraduate Studies, University of Health Sciences, Vientiane, Lao People’s Democratic Republic, 6 Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Abstract Background: Beriberi occurs in Vientiane, Lao PDR, among breastfed infants. Clinical disease may be the tip of an iceberg with subclinical thiamin deficiency contributing to other illnesses. Thiamin treatment could improve outcome. Methodology/Principal Findings: A cohort of 778 sick infants admitted during one year without clinical evidence of beriberi were studied prospectively and erythrocyte transketolase assays (ETK) performed. Biochemical thiamin deficiency was defined both in terms of the activation coefficient (a.31%) and basal ETK activity ,0.59 micromoles/min/gHb. Of the 778 infants, median (range) age was 5 (0–12) months, 79.2% were breastfed, 5.1% had a.31% and 13.4 % basal ETK,0.59 micromol