combined esophageal intraluminal impedance, ph and skin conductance monitoring to detect discomfort in gerd infants结合食道管腔内的阻抗、ph值和皮肤电导监测检测在gerd婴儿不适.pdfVIP

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combined esophageal intraluminal impedance, ph and skin conductance monitoring to detect discomfort in gerd infants结合食道管腔内的阻抗、ph值和皮肤电导监测检测在gerd婴儿不适.pdf

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combined esophageal intraluminal impedance, ph and skin conductance monitoring to detect discomfort in gerd infants结合食道管腔内的阻抗、ph值和皮肤电导监测检测在gerd婴儿不适

Combined Esophageal Intraluminal Impedance, pH and Skin Conductance Monitoring to Detect Discomfort in GERD Infants 1 2 3 1 4 Francesco Cresi *, Emanuele Castagno , Hanne Storm , Leandra Silvestro , Roberto Miniero , Francesco Savino1 1 Department of Pediatrics, University of Turin, S.Anna - Regina Margherita Children’s Hospital, Turin, Italy, 2 Division of Pediatric Emergency, S. Anna -Regina Margherita Children’s Hospital, Turin, Italy, 3 Skill Simulation lab, Medical faculty, University of Oslo, Oslo, Norway, 4 Department of Internal Medicine and Surgery, University ‘‘Magna Graecia’’, Catanzaro, Italy Abstract Background: The clinical significance of weakly acidic reflux in infants is unclear. Skin conductance is a novel not-invasive method to evaluate discomfort. The aim of our study was to evaluate reflux-induced discomfort in infants with gastroesophageal reflux disease using simultaneously combined skin conductance and esophageal multichannel intraluminal impedance and pH monitoring. Methodology/Principal Findings: Infants with gastroesophageal reflux symptoms were investigated for almost 20 hours divided into 120-second intervals. Temporal relationships between refluxes and discomfort were evaluated calculating the symptom association probability. Twelve infants aged 17–45 days were studied. Out of 194.38 hours of adequate artifact- free MII/pH and skin conductance monitoring, 584 reflux events were observed; 35.78% were positive for stress, of which 16.27% were acid and 83.73% weakly acidic. A significant association between refluxes and discomfort (p ,0.05) was present in all infants. The intervals with reflux events showed increased skin conductance