comparative genomics of serratia spp. two paths towards endosymbiotic life沙雷氏菌属的比较基因组学spp。两条路径对共生生活.pdfVIP

Comparative Genomics of Serratia spp.: Two Paths towards Endosymbiotic Life ´ 1 1,2 ´ 1,2 1,2 Alejandro Manzano-Marın , Araceli Lamelas , Andres Moya , Amparo Latorre * ` ´ ´ 1 Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Valencia, Spain, 2 Unidad Mixta de Investigacion en Genomica y Salud del Centro Superior ´ ´ ` de Investigacion en Salud Publica (Generalitat Valenciana) y del Institut Cavanilles de Biodiversitat i Biologia Evolutiva de la Universitat de Valencia, Valencia, Spain Abstract Symbiosis is a widespread phenomenon in nature, in which insects show a great number of these associations. Buchnera aphidicola, the obligate endosymbiont of aphids, coexists in some species with another intracellular bacterium, Serratia symbiotica. Of particular interest is the case of the cedar aphid Cinara cedri, where B. aphidicola BCc and S. symbiotica SCc need each other to fulfil their symbiotic role with the insect. Moreover, various features seem to indicate that S. symbiotica SCc is closer to an obligate endosymbiont than to other facultative S. symbiotica, such as the one described for the aphid Acirthosyphon pisum (S. symbiotica SAp). This work is based on the comparative genomics of five strains of Serratia, three free-living and two endosymbiotic ones (one facultative and one obligate) which should allow us