cry2 is associated with depressioncry2与抑郁症有关.pdfVIP

CRY2 Is Associated with Depression 1 ¨ 1 2 2 3 Catharina Lavebratt *, Louise K. Sjoholm , Pia Soronen , Tiina Paunio , Marquis P. Vawter , William E. 3 4 5 3 6 7 Bunney , Rolf Adolfsson , Yvonne Forsell , Joseph C. Wu , John R. Kelsoe , Timo Partonen , Martin Schalling1 1 Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden, 2 Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, 3 Functional Genomics Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine School of Medicine, Irvine, California, United States of America, 4 Division of Psychiatry, Department of ˚ ˚ Clinical Sciences, University of Umea, Umea, Sweden, 5 Department of Public Health Science, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden, 6 Department of Psychiatry, University of California San Diego School of Medicine, La Jolla, California, United States of America, 7 Mood, Depression and Suicidal Behaviour Unit, Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland Abstract Background: Abnormalities in the circadian clockwork often characterize patients with major depressive and bipolar disorders. Circadian clock genes are targets of interest in these patients. CRY2 is a circadian gene that participates in regulation of the evening oscillator. This is of interest in mood diso