cytotoxic aggregation and amyloid formation by the myostatin precursor protein细胞毒性聚合和肌肉生长抑制素前体蛋白淀粉样蛋白的形成.pdfVIP

Cytotoxic Aggregation and Amyloid Formation by the Myostatin Precursor Protein Carlene S. Starck, Andrew J. Sutherland-Smith* Institute of Molecular BioSciences, Massey University, Palmerston North, New Zealand Abstract Myostatin, a negative regulator of muscle growth, has been implicated in sporadic inclusion body myositis (sIBM). sIBM is the most common age-related muscle-wastage disease with a pathogenesis similar to that of amyloid disorders such as Alzheimer’s and Parkinson’s diseases. Myostatin precursor protein (MstnPP) has been