原创力文档decreased expression of sprouty2 in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder a correlation with bdnf expression减少表达sprouty2在精神分裂症和双相情感障碍的背外侧前额叶皮层bdnf的表达相关.pdfVIP
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decreased expression of sprouty2 in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder a correlation with bdnf expression减少表达sprouty2在精神分裂症和双相情感障碍的背外侧前额叶皮层bdnf的表达相关
Decreased Expression of Sprouty2 in the Dorsolateral
Prefrontal Cortex in Schizophrenia and Bipolar Disorder:
A Correlation with BDNF Expression
Anilkumar Pillai*
Department of Psychiatry and Health Behavior, Medical College of Georgia, Medical Research Service Line, Veterans Affairs Medical Center, Augusta, Georgia, United States
of America
Abstract
Background: Current theories on the pathophysiology of schizophrenia suggest altered brain plasticity such as decreased
neural proliferation and migration, delayed myelination, and abnormal synaptic modeling, in the brain of subjects with
schizophrenia. Though functional alterations in BDNF, which plays important role in neuroplasticity, are implicated in many
abnormalities found in schizophrenia, the regulatory mechanism(s) involved in the abnormal signaling of BDNF in
schizophrenia is not clear. The present study investigated whether Sprouty2, a regulator of growth factor signaling, is
abnormally expressed in schizophrenia, and is associated with the changes in BDNF mRNA in this disorder. The potential
effect of antipsychotic drugs on Sprouty2 expression was tested in adult rats.
Methods and Findings: Sprouty2 and BDNF gene expression were analyzed in dorsolateral prefrontal cortex samples from
the Stanley Array Collection. Quantitative real-time PCR analysis of RNA in 100 individuals (35 with schizophrenia, 31 with
bipolar disorder, and 34 psychiatrically normal controls) showed significantly decreased expression of Sprouty2 and BDNF in
both schizophrenia and bipolar disorder. Moreover, a significant correlation between these two genes existed in control,
schizophrenia and bipolar subjects. Long-term treatment with antipsychotic drugs, haloperidol and olanzapine, showed
differential effects on both Sprouty2 and BDNF mRNA and protein levels in the
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