defining obesity cut-off points for migrant south asians定义肥胖移民南亚的截止点.pdfVIP

Defining Obesity Cut-Off Points for Migrant South Asians 1 2 2 3 2 4 Laura J. Gray , Thomas Yates , Melanie J. Davies , Emer Brady , David R. Webb , Naveed Sattar , Kamlesh Khunti1* 1 Department of Health Sciences, University of Leicester, Leicester, United Kingdom, 2 Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom, 3 Department of Diabetes Research, University Hospitals of Leicester, Leicester, United Kingdom, 4 Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom Abstract Background: Body mass index (BMI) and waist circumference (WC) are used to define cardiovascular and type 2 diabetes risk. We aimed to derive appropriate BMI and WC obesity cut-off points in a migrant South Asian population. Methods: 4688 White Europeans and 1333 South Asians resident in the UK aged 40–75 years inclusive were screened for type 2 diabetes. Principal components analysis was used to derive a glycaemia, lipid, and a blood pressure factor. Regression models for each factor, adjusted for age and stratified by sex, were used to identify BMI and WC cut-off points in South Asians that correspond to those defined for White Europeans. Findings: For South Asian males, derived BMI obesity cut-off points equivalent to 30.0 kg/m2 in White Europeans were 2 2 2 2 22.6 kg/m (95% Confidence Interval (95% CI) 20.7 kg/m to 24.5 kg/m ) for the glycaemia factor, 26.0 kg/m (95% CI 24.7 kg/m2 2