defining human embryo phenotypes by cohort-specific prognostic factors定义人类胚胎cohort-specific表型的预后因素.pdfVIP

Defining Human Embryo Phenotypes by Cohort-Specific Prognostic Factors 1. 2. 1 1 1 1,3 Sunny H. Jun , Bokyung Choi , Lora Shahine , Lynn M. Westphal , Barry Behr , Renee A. Reijo Pera , 4 1 Wing H. Wong , Mylene W. M. Yao * 1 Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, United States of America, 2 Department of Applied Physics, School of Humanities and Sciences, Stanford University, Stanford, California, United States of America, 3 Center for Human Embryo and Embryonic Stem Cell Research and Education, Institute for Stem Cell Biology Regenerative Medicine, Stanford University, California, United States of America, 4 Department of Statistics, School of Humanities and Sciences, Stanford University, Stanford, California, United States of America Abstract Background: Hundreds of thousands of human embryos are cultured yearly at in vitro fertilization (IVF) centers worldwide, yet the vast majority fail to develop in culture or following transfer to the uterus. However, human embryo phenotypes have not been formally defined, and current criteria for embryo transfer largely focus on characteristics of individual embryos. We hypothesized that embryo cohort-specific variables describing sibling embryos as a group may predict developmental competence as measured by IVF cycle outcomes and serve to define human embryo phenotypes. Methodology/Principal Findings: We retrieved data for all 1117 IVF cycles performed in 2005 at Stanford University Medical Center, and further analyzed clinical data from the 665 fresh IVF, non-donor cycles and their associated 4144 embryos.