原创力文档defining the role of the mhc in autoimmunity a review and pooled analysis定义的角色mhc在自身免疫检查和汇总分析.pdfVIP
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defining the role of the mhc in autoimmunity a review and pooled analysis定义的角色mhc在自身免疫检查和汇总分析
Review
Defining the Role of the MHC in Autoimmunity: A Review
and Pooled Analysis
1 2 2 2,3,4
Michelle M. A. Fernando , Christine R. Stevens , Emily C. Walsh , Philip L. De Jager , Philippe
5 2,6 1* 2,5*
Goyette , Robert M. Plenge , Timothy J. Vyse , John D. Rioux
1 Section of Molecular Genetics and Rheumatology, Faculty of Medicine, Imperial College London, London, United Kingdom, 2 Program in Medical and Population
Genetics, Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America, 3 Department of Neurology,
Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, 4 Harvard Medical School/
´ ´ ´ ´
Partners Healthcare Center for Genetics and Genomics, Boston, Massachusetts, United States of America, 5 Universite de Montreal, Montreal Heart Institute, Montreal,
´
Quebec, Canada, 6 Harvard Medical School, Division of Rheumatology, Allergy and Immunology, Boston, Massachusetts, United States of America
disequilibrium (LD) and MHC-related genes exist outside the
Abstract: The major histocompatibility complex (MHC) is classically defined locus [4]. Of the 421 genes within the xMHC,
one of the most extensively studied regions in the human
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