deletion of the pluripotency-associated tex19.1 gene causes activation of endogenous retroviruses and defective spermatogenesis in mice删除的pluripotency-associated tex19.1基因导致激活内源性逆转录病毒和有缺陷的小鼠精子发生.pdfVIP

Deletion of the Pluripotency-Associated Tex19.1 Gene Causes Activation of Endogenous Retroviruses and Defective Spermatogenesis in Mice ¨ 1 1¤a 1,2,3 1 1,4 Rupert Ollinger , Andrew J. Childs , Hannah M. Burgess , Robert M. Speed , Pia R. Lundegaard , 1¤b 1,2,3 1 1,5 Nicola Reynolds , Nicola K. Gray , Howard J. Cooke *, Ian R. Adams * 1 MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom, 2 School of Clinical Sciences and Community Health, University of Edinburgh, Edinburgh, United Kingdom, 3 MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen’s Medical Research Institute, Edinburgh, United Kingdom, 4 Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom, 5 Edinburgh Cancer Research Centre, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom Abstract As genetic information is transmitted through successive generations, it passes between pluripotent cells in the early embryo and germ cells in the developing foetus and adult animal. Tex19.1 encodes a protein of unknown function, whose expression is restricted to germ cells and pluripotent cells. During male spermatogenesis, Tex19.1 expression is highest in mitotic spermatogonia and diminishes as these cells differentiate and progress through meiosis. In pluripotent stem cells, Tex19.1 expression is also downregulated upon differentiation. However, it is not clear whe