dementia before death in ageing societies— the promise of prevention and the reality痴呆之前死亡在老龄化社会中u2014u2014预防和现实的承诺.pdfVIP

PLoS MEDICINE Dementia before Death in Ageing Societies— The Promise of Prevention and the Reality 1* 2 3 2 Carol Brayne , Lu Gao , Michael Dewey , Fiona E. Matthews , Medical Research Council Cognitive Function and Ageing Study Investigators 1 Department of Public Health and Primary Care, Institute of Public Health, Cambridge University, Cambridge, United Kingdom, 2 Medical Research Council Biostatistics Unit, Institute of Public Health, Cambridge, United Kingdom, 3 Institute of Psychiatry, King’s College London, London, United Kingdom Funding: The Medical Research A B S T R A C T Council Cognitive Function and Ageing Study is supported by the Medical Research Council, United Kingdom. All research has been Background undertaken independently of the funding bodies. Dementia and severe cognitive impairment are very closely linked to ageing. The longer we live the more likely we are to suffer from these conditions. Given population increases in Competing Interests: The authors longevity it is important to understand not only risk and protective factors for dementia and have declared that no competing interests exist. severe cognitive impairment at given ages but also whether protection affects cumulative risk. This can be explored by examining the effect on cumulative risk by time of death of factors Academic Editor: Willem Van Gool, University of Amsterdam, found consistently to reduce risk at particular ages, such as education and social status. Netherlands Citation: Brayne C, Gao L, Dewey M, Methods and Findin