dendritic cell-derived exosomes promote natural killer cell activation and proliferation a role for nkg2d ligands and il-15rα树突细胞衍生液促进自然杀伤细胞的激活和增殖nkg2d配体il-15rα的角色.pdfVIP

Dendritic Cell-Derived Exosomes Promote Natural Killer Cell Activation and Proliferation: A Role for NKG2D Ligands and IL-15Ra 1,2 1,2 1,2,3 1,2,4 ´ 1,2 Sophie Viaud , Magali Terme , Caroline Flament , Julien Taieb , Fabrice Andre , Sophie 1,2 5 6 7 2 Novault , Bernard Escudier , Caroline Robert , Sophie Caillat-Zucman , Thomas Tursz , Laurence Zitvogel1,2,3,8., Nathalie Chaput1,2,3.* ´ ´ ´ 1 Institut National de la Sante et de la Recherche Medicale, Unite 805, Villejuif, France, 2 Institut Gustave Roussy, Villejuif, France, 3 Center of Clinical Investigations in ˆ ´ Biotherapies CICBT507, Institut Gustave Roussy, Villejuif, France, 4 Department of Hepatogastroenterology, Hopital Europeen Georges Pompidou, APHP, Paris, France, 5 Department of Immunotherapy, Institut Gustave Roussy, Villejuif, France, 6 Department of Dermatology, Institut Gustave Roussy, Villejuif, France, 7 Institut National de la ´ ´ ´ ˆ ´ ´ ´ ˆ Sante et de la Recherche Medicale, Unite 561, Hopital Saint Vincent de Paul, Paris, France, 8 Faculte de Medecine de l’universite Paris-Sud XI, Le Kremlin-Bicetre, France Abstract Dendritic cell (DC) derived-exosomes (Dex) are nanomeric vesicles harboring functional MHC/peptide complexes promoting T cell-dependent tumor rejection. In the first Pha