development of a small d-enantiomeric alzheimer’s amyloid-β binding peptide ligand for future in vivo imaging applications开发一个小d-enantiomeric阿尔茨海默氏症amyloid-β绑定肽配体为未来体内成像的应用程序.pdfVIP

Development of a Small D-Enantiomeric Alzheimer’s Amyloid-b Binding Peptide Ligand for Future In Vivo Imaging Applications 1 1 ¨ 1 2 1 Susanne Aileen Funke , Dirk Bartnik , Julian Marius Gluck , Kasia Piorkowska , Katja Wiesehan , 2 3 3 2 4,5 2 Urs Weber , Balazs Gulyas , Christer Halldin , Andrea Pfeifer , Christian Spenger , Andreas Muhs , Dieter Willbold1,6* ¨ ¨ 1 Forschungszentrum Julich, ICS-6, Julich, Germany, 2 AC Immune, PSE Building B, EPFL, Lausanne, Switzerland, 3 Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, 4 Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden, 5 Prodema ¨ ¨ ¨ ¨ Management AG, Bronschhofen, Switzerland, 6 Institut fur Physikalische Biologie, Heinrich-Heine-Universitat Dusseldorf, Dusseldorf, Germany Abstract Alzheimer’s disease (AD) is a devastating disease affecting predominantly the aging population. One of the characteristic pathological hallmarks of AD are neuritic plaques, consisting of amyloid-b peptide (Ab). While there has been some advancement in diagnostic classification of AD patients according to their clinical severity, no fully reliable method for pre- symptomatic diagnosis of AD is available. To enable such early diagnosis, which will allow the initiation of treatments early in the disease progress, neuroimaging tools are under developmen