developmental transcriptomic features of the carcinogenic liver fluke, clonorchis sinensis发育的转录组特征致癌肝吸虫,clonorchis制成.pdfVIP

Developmental Transcriptomic Features of the Carcinogenic Liver Fluke, Clonorchis sinensis 1,2. 2,4. 2. 3 1 2 Won Gi Yoo , Dae-Won Kim , Jung-Won Ju , Pyo Yun Cho , Tae Im Kim , Shin-Hyeong Cho , 4 4 5 1 Sang-Haeng Choi , Hong-Seog Park *, Tong-Soo Kim *, Sung-Jong Hong * 1 Department of Medical Environmental Biology and Research Center for Biomolecules and Biosystems, Chung-Ang University College of Medicine, Seoul, Republic of Korea, 2 Division of Malaria and Parasitic Diseases, National Institute of Health, Korea Centers for Disease Control and Prevention, Osong, Chungbuk, Republic of Korea, 3 Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine, Chonbuk, Republic of Korea, 4 Genome Research Center, Korea Research Institute of Bioscience and Biotechnology and University of Science and Technology, Daejeon, Republic of Korea, 5 Department of Parasitology, Inha University School of Medicine, Incheon, Republic of Korea Abstract Clonorchis sinensis is the causative agent of the life-threatening disease endemic to China, Korea, and Vietnam. It is estimated that about 15 million people are infected with this fluke. C. sinensis provokes inflammation, epithelial hyperplasia, and periductal fibrosis in bile ducts, and may cause cholangiocarcinoma in chronically infected individuals. Accumulation of a large amount of biological information about the adult stage of this liver fluke in recent years has advanced our understanding of the pathological interplay between this parasite and its hosts. However, no developmenta