diabetes mellitus increases the risk of active tuberculosis a systematic review of 13 observational studies糖尿病会增加活动性结核病的风险的系统回顾13观察性研究.pdfVIP

PLoS MEDICINE Diabetes Mellitus Increases the Risk of Active Tuberculosis: A Systematic Review of 13 Observational Studies * Christie Y. Jeon , Megan B. Murray Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America Funding: CYJ is supported by a A B S T R A C T departmental grant from the Department of Epidemiology at Harvard School of Public Health. The department had no role in study Background design, data collection and analysis, decision to publish, or preparation Several studies have suggested that diabetes mellitus (DM) increases the risk of active of the manuscript. tuberculosis (TB). The rising prevalence of DM in TB-endemic areas may adversely affect TB Competing Interests: The authors control. We conducted a systematic review and a meta-analysis of observational studies have declared that no competing assessing the association of DM and TB in order to summarize the existing evidence and to interests exist. assess methodological quality of the studies. Academic Editor: Brian Williams, World Health Organization, Methods and Findings Switzerland Citation: Jeon CY, Murray MB (2008) We searched the PubMed and EMBASE databases to identify observational studies that had Diabetes mellitus increases the risk reported an age-adjusted quantitative estimate of the association between DM and active TB of active tuberculosis: A systematic disease. The search yielded 13 observational studies (n ¼ 1,786,212 participants) with 17,698 TB review of 13 observational studies. PLoS Med 5(7): e152. doi:1