disrupted intercellular communication causes a disfiguring birth defect破坏细胞间的沟通会导致毁容出生缺陷.pdfVIP

Synopses of Research Articles A Flexible Syntaxin Solves the Mystery of the SNAREd Munc Richard Robinson | DOI: 10.1371/journal.pbio.0040359 Fusion of two plasma membranes is been shown that the addition of central to exocytosis, the process by synaptobrevin drives syntaxin (without which a cell secretes neurotransmitters, Munc18-1) in conjunction with digestive enzymes, and other products. SNAP-25 (the third SNARE essential If you believe the simple diagrams in for neuroexocytosis) into SNARE introductory biology textbooks, you’d complexes. They reasoned that adding think this fusion occurs as soon as two synaptobrevin to syntaxin–Munc18-1 membranes touch. Not so—in fact, would not drive syntaxin into SNARE membrane fusion requires interaction complexes if syntaxin remained among a complex set of proteins in closed. Conversely, if syntaxin could the membranes, collectively termed partially open while bound to Munc18- SNARE proteins. SNAREs are assisted 1, it would be able to interact with by a second group, called SM proteins, synaptobrevin and join the SNARE which bind to them and help prom