dopamine transporters in striatum correlate with deactivation in the default mode network during visuospatial attention在纹状体多巴胺转运蛋白与失活在默认模式网络视觉空间的关注.pdfVIP

Dopamine Transporters in Striatum Correlate with Deactivation in the Default Mode Network during Visuospatial Attention 1 1,2 3 1 1 4 Dardo Tomasi *, Nora D. Volkow , Ruiliang Wang , Frank Telang , Gene-Jack Wang , Linda Chang , Thomas Ernst4, Joanna S. Fowler3 1 National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, United States of America, 2 National Institute on Drug Abuse, Bethesda, Maryland, United States of America, 3 Medical Department, Brookhaven National Laboratory, Upton, New York, United States of America, 4 Department of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America Abstract Background: Dopamine and dopamine transporters (DAT, which regulate extracellular dopamine in the brain) are implicated in the modulation of attention but their specific roles are not well understood. Here we hypothesized that dopamine modulates attention by facilitation of brain deactivation in the default mode network (DMN). Thus, higher striatal DAT levels, which would result in an enhanced clearance of dopamine and hence weaker dopamine signals, would be associated to lower deactivation in the DMN during an attention task. Methodology/Principal Findings: For this purpose we assessed the relationship between DAT in striatum (measured with positron emission tomography and [11C]cocaine used as DAT radiotracer) and brain activation and deactivation during a parametric visual attention task (measured with blood oxygenation level dependent functional magnetic resonance imaging) in healthy controls. We show that DAT availability in caudate and putamen had a negative correlat