dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task pharmacological studies and the role of individual differences多巴胺能调制effort-related选择行为的评估进步比食物喂养选择任务药理研究和个体差异的作用.pdfVIP

Dopaminergic Modulation of Effort-Related Choice Behavior as Assessed by a Progressive Ratio Chow Feeding Choice Task: Pharmacological Studies and the Role of Individual Differences 1 1,2 1 ´ 1,2 3 Patrick A. Randall , Marta Pardo , Eric J. Nunes , Laura Lopez Cruz , V. Kiran Vemuri , 3 4 ¨ 4 ` 1,2 1 Alex Makriyannis , Younis Baqi , Christa E. Muller , Merce Correa , John D. Salamone * ` 1 Department of Psychology, University of Connecticut, Storrs, Connecticut, United States of America, 2 Area de Psicobiologia, Campus de Riu Sec, Universitat Jaume I, ´ Castello, Spain, 3 Center for Drug Discovery, Northeastern University, Boston, Massachusetts, United States of America, 4 Pharma-Zentrum Bonn, Pharmazeutisches ¨ Institut, Pharmazeutische Chemie, Universitat Bonn, Bonn, Germany Abstract Mesolimbic dopamine (DA) is involved in behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from food-reinforced tasks with high response requirements, and instead select less effortful food-seeking behaviors. In the present study, the effects of several drug treatments were assessed using a progressive ratio (PROG)/chow feeding concurrent choice task. With this task, rats can lever press on a PROG schedule reinforced by a preferred h