early-life determinants of total and hdl cholesterol concentrations in 8-year-old children; the piama birth cohort study早期的决定因素总和高密度脂蛋白胆固醇浓度的8岁的孩子;.pdfVIP

Early-Life Determinants of Total and HDL Cholesterol Concentrations in 8-Year-Old Children; The PIAMA Birth Cohort Study 1,2 1,3 ¨ 3 4 5 Marga B.M. Bekkers *, Bert Brunekreef , Henriette A. Smit , Marjan Kerkhof , Gerard H. Koppelman , Marieke Oldenwening1, Alet H. Wijga2 1 Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands, 2 Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands, 3 Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands, 4 Department of Epidemiology and Bioinformatics, University of Groningen, Groningen, The Netherlands, 5 Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, Beatrix Children’s Hospital, Groningen, The Netherlands Abstract Background: Adult cholesterol concentrations might be influenced by early-life factors, such as breastfeeding and birth weight, referred to as ‘‘early programming’’. How such early factors exert their influence over the life course is still poorly understood. Evidence from studies in children and adolescents is scarce and conflicting. We investigated the influence of 6 different perinatal risk factors on childhood total and HDL cholesterol concentrations and total-to-HDL cholesterol ratio measured at 8 years of age, and additionally we studied the role of the child’s current Body Mass Index (BMI). Methods: Anthropometric measures and blood plasma samples were collected during a medical examination in 751 8-year- old children participating in the prospective Prevention and Incidence of Asthma and Mite Allergy (PIAM