ectodermal influx and cell hypertrophy provide early growth for all murine mammary rudiments, and are differentially regulated among them by gli3外胚层的涌入和细胞肥大提供早期增长小鼠乳腺基础知识,和被激活其中差别监管.pdfVIP

Ectodermal Influx and Cell Hypertrophy Provide Early Growth for All Murine Mammary Rudiments, and Are Differentially Regulated among Them by Gli3 1,2 1 1 1 1 3 May Yin Lee , Victor Racine , Peter Jagadpramana , Li Sun , Weimiao Yu , Tiehua Du , Bradley 4 5 5 6 5¤ 7 Spencer-Dene , Nicole Rubin , Lendy Le , Delphine Ndiaye , Saverio Bellusci , Klaus Kratochwil , Jacqueline M. Veltmaat1,8* 1 Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research), Singapore, Singapore, 2 Graduate School for Integrative Sciences and Engineering, National University of Singapore, Centre for Life Sciences (CeLS), Singapore, Singapore, 3 Bio-Informatics Institute, A*STAR (Agency for Science, Technology and Research), Singapore, Singapore, 4 Experimental Histopathology Laboratory, Cancer Research UK London Research Institute, London, United Kingdom, 5 Developmental Biology Program, The Saban Research Institute of Children’s Hospital Los Angeles, Los Angeles, California, United States of America, 6 Institut Curie/ ` CNRS-UMR144, Equipe de Morphogenese Cellulaire et Progression Tumorale, Paris, France, 7 Molecular Biology Institute, Salzburg, Austria, 8 Department of Anatomy, Yong Loo Lin School of Medicine, National University Health System, Singapore, Singapore Abstract Mammary gland development starts in utero with one or several pairs of mammary rudiments (MRs) budding from the surface ectodermal component of the mammalian embryonic skin. Mice develop five pairs, numbered MR1 to MR5 from pectoral to inguinal positio