effect of acupuncture in mild cognitive impairment and alzheimer disease a functional mri study针灸的效果在轻度认知障碍和阿尔茨海默病功能核磁共振成像研究.pdfVIP

Effect of Acupuncture in Mild Cognitive Impairment and Alzheimer Disease: A Functional MRI Study 1 2 3 1 4 4 3 Zhiqun Wang , Binbin Nie , Donghong Li , Zhilian Zhao , Ying Han , Haiqing Song , Jianyang Xu , 2 1 1,5 Baoci Shan , Jie Lu *, Kuncheng Li * 1 Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China, 2 Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China, 3 General Hospital of Chinese People’s Armed Police Forces, Beijing China, 4 Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China, 5 Key Laboratory for Neurodegenerative Diseases, Ministry of Education, Beijing, China Abstract We aim to clarify the mechanisms of acupuncture in treating mild cognitive impairment (MCI) and Alzheimer disease (AD) by using functional magnetic resonance imaging (fMRI). Thirty-six right-handed subjects (8 MCI patients, 14 AD patients, and 14 healthy elders) participated in this study. Clinical and neuropsychological examinations were performed on all the subjects. MRI data acquisition was performed on a SIEMENS verio 3-Tesla scanner. The fMRI study used a single block experimental design. We first acquired the baseline resting state data in the initial 3 minutes; we then acquired the fMRI data during the procession of acupuncture stimulation on the acupoints of Tai chong and Hegu for the following 3 minutes. Last, we acquired fMRI data for another 10 minutes after the needle was withdrawn. The preprocessing and data analysis were performed using the statistical parametric mapping (SPM8) software. Then the two-sample t-tests were performed between each two groups of different states. We fou