effect of composition interactions on the dose response of an n-isopropylacrylamide gel dosimeter成分相互作用的效应n-isopropylacrylamide凝胶剂量计的剂量反应.pdfVIP

Effect of Composition Interactions on the Dose Response of an N-Isopropylacrylamide Gel Dosimeter Yuan-Jen Chang1,2*, Bor-Tsung Hsieh3 1 Department of Management Information Systems, Central Taiwan University of Science and Technology, Taichung, Taiwan, Republic of China, 2 Institute of Biomedical Engineering and Material Science, Central Taiwan University of Science and Technology, Taichung, Taiwan, Republic of China, 3 Department of Medical Imaging and Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan, Republic of China Abstract In this study, a two-level full factorial design was used to identify the effects of the interactions between compositions in an N-isopropylacrylamide (NIPAM) gel dosimeter involving the following variables: (A) gelatin, (B) NIPAM, (C) the crosslinker N, N9-methylene-bis-acrylamide (Bis), and (D) the antioxidant tetrakis (hydroxymethyl) phosphonium chloride (THPC). The dose range was from 0 Gy to 5 Gy. Optical computed tomography was used to scan the polymer gel dosimeter. Each component was set to two levels for all four variables, including (A) 4% and 6%, (B) 4% and 6%, (C) 2% and 4%, as well as (D) 5 and 15 mM. Response surface methodology and a central composite design were adopted for the quantitative investigation of the respective interaction effects on the dose response curve of the gel. The results showed that the contributions of the interaction effects, i.e., AB (6.22%), AC (8.38%), AD (7.74%), BC (9.44%), ABC (18.24%), BCD (12.66%), and ABCD (13.4%), were greater than those of the four main effects, accounting for over 76.08% of the total variability. These results also indicated that the NIPAM gel recipe with the highest sensitivity was at 40%C (mass fraction of Bis). Citation: Chang Y-J, Hsieh B-T (2012) Effect of Composition Interactions on the Dose Response of an N-Isopropylacrylamide Gel Dosimeter. P