effect of constitution on mass of individual organs and their association with metabolic rate in humans—a detailed view on allometric scaling宪法对个人器官的质量的影响及其与代谢率在人类一个异速生长的扩展的详细视图.pdfVIP

Effect of Constitution on Mass of Individual Organs and Their Association with Metabolic Rate in Humans—A Detailed View on Allometric Scaling ¨ 1 2 1 1 3 ¨ 3 Manfred J. Muller *, Dirk Langemann , Isabel Gehrke , Wiebke Later , Martin Heller , Claus C. Gluer , Steven B. Heymsfield4, Anja Bosy-Westphal1 ¨ ¨ ¨ 1 Institut fur Humanernahrung und Lebensmittelkunde, Christian-Albrechts-Universitat zu Kiel, Kiel, Germany, 2 Institute of Computational Mathematics, Technical ¨ ¨ University Braunschweig, Braunschweig, Germany, 3 Klinik fur Diagnostische Radiologie, Universitatsklinikum Schleswig Holstein, Kiel, Germany, 4 Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America Abstract Resting energy expenditure (REE)-power relationships result from multiple underlying factors including weight and height. In addition, detailed body composition, including fat free mass (FFM) and its components, skeletal muscle mass and internal organs with high metabolic rates (i.e. brain, heart, liver, kidneys), are major determinants of REE. Since the mass of individual organs scales to height as well as to weight (and, thus, to constitution), the variance in these associations may also add to the variance in REE. Here we address body composition (measured by magnetic resonance imaging) and REE (assessed by indirect calorimetry) in a group of 330 healthy volunteers differing with respect to age (17–78 years), sex (61% female) and BMI (15.9–47.8 kg/m2). Using three dimensional data interpolation we found that the inter-individual variance related t