effect of high- versus low-intensity supervised aerobic and resistance training on modifiable cardiovascular risk factors in type 2 diabetes; the italian diabetes and exercise study (ides)高和低强度有氧监管和阻力训练对修改的心血管危险因素在2型糖尿病;.pdfVIP

Effect of High- versus Low-Intensity Supervised Aerobic and Resistance Training on Modifiable Cardiovascular Risk Factors in Type 2 Diabetes; The Italian Diabetes and Exercise Study (IDES) Stefano Balducci1,2,3., Silvano Zanuso4., Patrizia Cardelli1,5, Laura Salvi1,2, Alessandra Bazuro1,2, 1,2 1,2 1,3 1,2 6 Luca Pugliese , Carla Maccora , Carla Iacobini , Francesco G. Conti , Antonio Nicolucci , Giuseppe Pugliese1,2*, for the Italian Diabetes Exercise Study (IDES) Investigators 1 Department of Clinical and Molecular Medicine, ‘‘La Sapienza’’ University, Rome, Italy, 2 Diabetes Unit, Sant’Andrea Hospital, Rome, Italy, 3 Metabolic Fitness Association, Monterotondo, Rome, Italy, 4 School of Science, University of Greenwich, London, United Kingdom, 5 Laboratory of Clinical Chemistry, Sant’Andrea Hospital, Rome, Italy, 6 Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, S. Maria Imbaro, Chieti, Italy Abstract Background: While current recommendations on exercise type and volume have strong experimental bases, there is no clear evidence from large-sized studies indicating whether increasing training intensity provides additional benefits to subjects with type 2 diabetes. Objective: To compare the effects of moderate-to-high intensity (HI) versus low-to-moderate intensity (LI) training of equal energy cost, i.e. exercise volume, on modifiable cardiovascular risk factors. Design: Pre-specified sub-analysis of the Italian Diabetes and Exercise Study (IDES), a randomized multicenter prospective trial comparing a supervised exercise intervention with standard care for 12 months (2005–2006). Setting: Twenty-two outpatient diabetes clinics across Italy. Patients: Sedentary patients with type 2