elderly subjects have a delayed antibody response and prolonged viraemia following yellow fever vaccination a prospective controlled cohort study老年人有一个延迟抗体反应和长期病毒血症黄热病疫苗接种后一个前瞻性队列研究控制.pdfVIP

Elderly Subjects Have a Delayed Antibody Response and Prolonged Viraemia following Yellow Fever Vaccination: A Prospective Controlled Cohort Study 1 1 1 ¨ 1 2 Anna H. Roukens *, Darius Soonawala , Simone A. Joosten , Adriette W. de Visser , Xiaohong Jiang , 3 4 1 2 1 Kees Dirksen , Marjolein de Gruijter , Jaap T. van Dissel , Peter J. Bredenbeek , Leo G. Visser 1 Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands, 2 Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands, 3 Municipal Health Center Hollands Midden, The Hague, The Netherlands, 4 Municipal Health Center Leiden, Leiden, The Netherlands Abstract Background: Yellow fever vaccination (YF-17D) can cause serious adverse events (SAEs). The mechanism of these SAEs is poorly understood. Older age has been identified as a risk factor. We tested the hypothesis that the humoral immune response to yellow fever vaccine develops more slowly in elderly than in younger subjects. Method: We vaccinated young volunteers (18–28 yrs, N = 30) and elderly travelers (60–81 yrs, N = 28) with YF-17D and measured their neutralizing antibody titers and plasma YF-17D RNA copy numbers before vaccination and 3, 5, 10, 14 and 28 days after vaccination. Results: Ten days after vaccination seroprotection was attained by 77% (23/30) of the young participants and by 50% (14/ 28) of the elderly participants (p = 0.03). Accordingly, the Geometric Mean Titer of younger participants was higher than the GMT of the elderly participants. At day 10 the difference was +2.9 IU/ml (95