economic analysis of pandemic influenza vaccination strategies in singapore在新加坡经济分析的大流行性流感疫苗接种战略.pdfVIP

Economic Analysis of Pandemic Influenza Vaccination Strategies in Singapore 1,2,3 1 4 5 6,7 8 Vernon J. Lee *, Mei Yin Tok , Vincent T. Chow , Kai Hong Phua , Eng Eong Ooi , Paul A. Tambyah , Mark I. Chen7,9 1 Center for Health Services Research, National University of Singapore, Singapore, Singapore, 2 Department of Epidemiology and Public Health, National University of Singapore, Singapore, Singapore, 3 Biodefence Center, Ministry of Defence, Singapore, Singapore, 4 Department of Microbiology, National University of Singapore, Singapore, Singapore, 5 Lee Kuan Yew School of Public Policy, Singapore, Singapore, 6 Defence Science Organization National Laboratories, Singapore, Singapore, 7 Duke- National University of Singapore Graduate Medical School, Singapore, Singapore, 8 Department of Medicine, National University of Singapore, Singapore, Singapore, 9 Communicable Disease Center, Tan Tock Seng Hospital, Singapore, Singapore Abstract Background: All influenza pandemic plans advocate pandemic vaccination. However, few studies have evaluated the cost- effectiveness of different vaccination strategies. This paper compares the economic outcomes of vaccination compared with treatment with antiviral agents alone, in Singapore. Methodology: We analyzed the economic outcomes of pandemic vaccination (immediate vaccination and vaccine stockpiling) compared with treatment-only in Singapore using a decision-based model to perform cost-benefit and cost- effectiveness analyses. We also explored the annual insurance premium (willingness to pay) depending on the perceived risk of the next pandemic occurring. Principal Findings: The treatme