economic analysis of pandemic influenza vaccination strategies in singapore在新加坡经济分析的大流行性流感疫苗接种战略.pdfVIP
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economic analysis of pandemic influenza vaccination strategies in singapore在新加坡经济分析的大流行性流感疫苗接种战略
Economic Analysis of Pandemic Influenza Vaccination
Strategies in Singapore
1,2,3 1 4 5 6,7 8
Vernon J. Lee *, Mei Yin Tok , Vincent T. Chow , Kai Hong Phua , Eng Eong Ooi , Paul A. Tambyah ,
Mark I. Chen7,9
1 Center for Health Services Research, National University of Singapore, Singapore, Singapore, 2 Department of Epidemiology and Public Health, National University of
Singapore, Singapore, Singapore, 3 Biodefence Center, Ministry of Defence, Singapore, Singapore, 4 Department of Microbiology, National University of Singapore,
Singapore, Singapore, 5 Lee Kuan Yew School of Public Policy, Singapore, Singapore, 6 Defence Science Organization National Laboratories, Singapore, Singapore, 7 Duke-
National University of Singapore Graduate Medical School, Singapore, Singapore, 8 Department of Medicine, National University of Singapore, Singapore, Singapore,
9 Communicable Disease Center, Tan Tock Seng Hospital, Singapore, Singapore
Abstract
Background: All influenza pandemic plans advocate pandemic vaccination. However, few studies have evaluated the cost-
effectiveness of different vaccination strategies. This paper compares the economic outcomes of vaccination compared with
treatment with antiviral agents alone, in Singapore.
Methodology: We analyzed the economic outcomes of pandemic vaccination (immediate vaccination and vaccine
stockpiling) compared with treatment-only in Singapore using a decision-based model to perform cost-benefit and cost-
effectiveness analyses. We also explored the annual insurance premium (willingness to pay) depending on the perceived
risk of the next pandemic occurring.
Principal Findings: The treatme
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