elevated hemostasis markers after pneumonia increases one-year risk of all-cause and cardiovascular deaths高架止血标记后肺炎增加一年期全因死亡和心血管的风险.pdfVIP

Elevated Hemostasis Markers after Pneumonia Increases One-Year Risk of All-Cause and Cardiovascular Deaths 1,2 3 1,2 1,2 2,4 Sachin Yende *, Gina D’Angelo , Florian Mayr , John A. Kellum , Lisa Weissfeld , A. Murat 1,2 1,2 5 1,2 Kaynar , Tammy Young , Kaikobad Irani , Derek C. Angus , for the GenIMS Investigators 1The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 2 Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 3 Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America, 4 Division of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 5 Division of Cardiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Abstract Background: Acceleration of chronic diseases, particularly cardiovascular disease, may increase long-term mortality after community-acquired pneumonia (CAP), but underlying mechanisms are unknown. Persistence of the prothrombotic state that occurs during an acute infection may increase risk of subsequent atherothrombosis in patients with pre-existing cardiovascular disease and increase subsequent risk of death. We hypothesized that circulating hemostasis markers activated during CAP persist at hospital discharge, when patients appear to have recovered clinically, and are associated with higher mo