noise amplification in human tumor suppression following gamma irradiation在人类肿瘤抑制γ辐照后噪声放大.pdfVIP

Noise Amplification in Human Tumor Suppression following Gamma Irradiation Bo Liu1,2, Shiwei Yan1,3*, Xingfa Gao2 1 Key Laboratory of Beam Technology and Material Modification of Ministry of Education, College of Nuclear Science and Technology, Beijing Normal University, Beijing, China, 2 Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China, 3 Beijing Radiation Center, Beijing, China Abstract The influence of noise on oscillatory motion is a subject of permanent interest, both for fundamental and practical reasons. Cells respond properly to external stimuli by using noisy systems. We have clarified the effect of intrinsic noise on the dynamics in the human cancer cells following gamma irradiation. It is shown that the large amplification and increasing mutual information with delay are due to coherence resonance. Furthermore, frequency domain analysis is used to study the mechanisms. Citation: Liu B, Yan S, Gao X (2011) Noise Amplification in Human Tumor Suppression following Gamma Irradiation. PLoS ONE 6(8): e22487. doi:10.1371/ journal.pone.0022487 Editor: Matjaz Perc, University of Maribor, Slovenia Received May 12, 2011; Accepted June 22, 2011; Published August 5, 2011 Copyright: 2011 Liu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: SY acknowledges support from the National Natural Science Foundation of China under Grant No. the Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Personnel of China under Grant No. MOP2006138, and the Fundamental Research Funds for the Central Universities. The funder