non-additive coupling enables propagation of synchronous spiking activity in purely random networks非附加耦合使传播活动纯粹的随机网络同步攀升.pdfVIP

Non-Additive Coupling Enables Propagation of Synchronous Spiking Activity in Purely Random Networks 1 2 Raoul-Martin Memmesheimer *, Marc Timme 1 Department for Neuroinformatics, Radboud University Nijmegen, Nijmegen, Netherlands, 2 Network Dynamics Group, Max Planck Institute for Dynamics Self- ¨ Organization, and Bernstein Center for Computational Neuroscience, Gottingen, Germany Abstract Despite the current debate about the computational role of experimentally observed precise spike patterns it is still theoretically unclear under which conditions and how they may emerge in neural circuits. Here, we study spiking neural networks with non-additive dendritic interactions that were recently uncovered in single-neuron experiments. We show that supra-additive dendritic interactions enable the persistent propagation of synchronous activity already in purely random networks without superimposed structures and explain the mechanism underlying it. This study adds a novel perspective on the dynamics of networks with nonlinear interactions in general and presents a new viable mechanism for the occurrence of patterns of precisely timed spikes in recurrent networks. Citation: Memmesheimer R-M, Timme M (2012) Non-Additive Coupling Enables Propagation of Synchronous Spiking Activity in Purely Random Networks. PLoS Comput Biol 8(4): e1002384. doi:10.1371/journal.pcbi.1002384 ´ Editor: Lyle J. Graham, Universite Paris Descartes, Centre National de la Recherche Scientifique, France Received July 14, 2011; Accepted December 29, 2011; Published April 19, 2012 Copyright: 2012 Memmesheimer, Timme. This is an open-access article distributed under the t