non-invasive evaluation of cystic fibrosis related liver disease in adults with arfi, transient elastography and different fibrosis scores非侵入性评价囊性纤维化相关肝病与arfi成年人,瞬时弹性成像和不同纤维化的分数.pdfVIP

Non-Invasive Evaluation of Cystic Fibrosis Related Liver Disease in Adults with ARFI, Transient Elastography and Different Fibrosis Scores 1. 1. 2 ¨ 2 3 2 Thomas Karlas , Marie Neuschulz , Annett Oltmanns , Andrea Guttler , David Petroff , Hubert Wirtz , 4 ¨ 1 1 ¨ 1,5 1,5 Jochen G. Mainz , Joachim Mossner , Thomas Berg , Michael Troltzsch , Volker Keim , Johannes Wiegand 1* 1 University Hospital Leipzig, Department of Internal Medicine, Dermatology and Neurology, Medical Clinic for Gastroenterology and Rheumatology, Leipzig, Germany, 2 University Hospital Leipzig, Department of Internal Medicine, Dermatology and Neurology, Division of Pulmonary Medicine, Leipzig, Germany, 3 University of Leipzig, Coordination Center for Clinical Trials, Leipzig, Germany, 4 University Hospital Jena, Department of Pediatrics, Jena, Germany, 5 University Hospital Leipzig, Interdisciplinary Ultrasound Unit, Leipzig, Germany Abstract Background: Cystic fibrosis-related liver disease (CFLD) is present in up to 30% of cystic fibrosis patients and can result in progressive liver failure. Diagnosis of CFLD is challenging. Non-invasive methods for staging of liver fibrosis display an interesting diagnostic approach for CFLD detection. Aim: We evaluated transient elastography (TE), acoustic radiation force impulse imaging (ARFI), and fibrosis indices for CFLD detection. Methods: TE and ARFI were performed in 55 adult CF patients. In addition, AST/Platelets-Ratio-Index (APRI), and Forns’ score were calculated. Healthy probands and patients wit