nonlinear gap junctions enable long-distance propagation of pulsating calcium waves in astrocyte networks非线性缝隙连接使远距离的脉动钙波传播星形胶质细胞网络.pdfVIP

Nonlinear Gap Junctions Enable Long-Distance Propagation of Pulsating Calcium Waves in Astrocyte Networks 1 ` 1 2,3 4 1,2 Mati Goldberg , Maurizio De Pitta , Vladislav Volman , Hugues Berry *, Eshel Ben-Jacob * 1 School of Physics and Astronomy, Tel Aviv University, Ramat Aviv, Israel, 2 Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, ˆ United States of America, 3 Computational Neurobiology Lab, The Salk Institute, La Jolla, California, United States of America, 4 Project-Team Combining, INRIA Rhone- Alpes, Villeurbanne, France Abstract A new paradigm has recently emerged in brain science whereby communications between glial cells and neuron-glia interactions should be considered together with neurons and their networks to understand higher brain functions. In particular, astrocytes, the main type of glial cells in the cortex, have been shown to communicate with neurons and with each other. They are thought to form a gap-junction-coupled syncytium supporting cell-cell communication via propagating Ca2+ waves. An identified mode of propagation is based on cytoplasm-to-cytoplasm transport of inositol trisphosphate (IP ) through gap junctions that locally trigger Ca2+ pulses via IP -dependent Ca2+-induced Ca2+ release. It is, 3 3 however, currently unknown whether