non-motor symptoms in patients with parkinson’s disease – correlations with inflammatory cytokines in serum非症状帕金森氏症患者与血清中炎性细胞因子的相关性.pdfVIP

Non-Motor Symptoms in Patients with Parkinson’s Disease – Correlations with Inflammatory Cytokines in Serum 1,2 1 1,3 4,5 4,5 5,6 Daniel Lindqvist *, Eli Kaufman , Lena Brundin , Sara Hall , Yulia Surova , Oskar Hansson ˚ 1 Department of Clinical Sciences, Section for Psychiatry, Lund University, Lund, Sweden, 2 Psychiatry Skane, Lund, Sweden, 3 Department of Translational Science and Molecular Medicine, Michigan State University, Grand Rapids, Michigan, United States of America, 4 Department of Clinical Sciences, Lund University, Lund, Sweden, ˚ ¨ 5 Department of Neurology, Skane University Hospital, Lund, Sweden, 6 Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmo, Sweden Abstract Background: Parkinson’s Disease (PD) is the second most common neurodegenerative disorder of the central nervous system. Motor symptoms are the focus of pharmacotherapy, yet non-motor features of the disease (e.g. fatigue, mood disturbances, sleep disturbances and symptoms of anxiety) are both common and disabling for the patient. The pathophysiological mechanisms behind the non-motor symptoms in PD are yet to be untangled. The main objective of this study was to investigate associations between pro-inflammatory substances and non-motor symptoms in patients with PD. Methods and Materials: We measured C-reactive protein, interleukin (IL)-6, soluble IL-2 receptor (sIL-2R