nonlinear time series analysis of nodulation factor induced calcium oscillations evidence for deterministic chaos非线性时间序列分析的分枝因子诱导钙振荡的证据确定的混乱.pdfVIP

Nonlinear Time Series Analysis of Nodulation Factor Induced Calcium Oscillations: Evidence for Deterministic Chaos? 1 2 1 3 2 1 Saul Hazledine , Jongho Sun , Derin Wysham , J. Allan Downie , Giles E. D. Oldroyd , Richard J. Morris * 1 Computational and Systems Biology, John Innes Centre, Norwich, United Kingdom, 2 Disease and Stress Biology, John Innes Centre, Norwich, United Kingdom, 3 Department of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom Abstract Legume plants form beneficial symbiotic interactions with nitrogen fixing bacteria (called rhizobia), with the rhizobia being accommodated in unique structures on the roots of the host plant. The legume/rhizobial symbiosis is responsible for a significant proportion of the global biologically available nitrogen. The initiation of this symbiosis is governed by a characteristic calcium oscillation within the plant root hair cells and this signal is activated by the rhizobia. Recent analyses on calcium time series data have suggested that stochastic effects have a large role to play in defining the nature of the oscillations. The use of multiple nonlinear time series techniques, however, suggests an alternative interpretation, namely deterministic chaos. We provide an extensive, nonlinear time series analysis on the nature of this calcium oscillation response. We build up evidence through a series of techniques that test for determinism, quantify linear and nonlinear components, and measure the local divergence of the system. Chaos is common in nature and it seems plausible that properties of chaotic dynamics might be exploited by biological syste