notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites等级是一个关键组成部分鼠标somitogenesis振荡器和对体节的形成至关重要.pdfVIP

Notch Is a Critical Component of the Mouse Somitogenesis Oscillator and Is Essential for the Formation of the Somites 1 2. 1. 2 3,4 Zoltan Ferjentsik , Shinichi Hayashi , J. Kim Dale , Yasumasa Bessho , An Herreman , Bart De 3,4 5 5 1 Strooper , Gonzalo del Monte , Jose Luis de la Pompa , Miguel Maroto * 1 Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom, 2 Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan, 3 Department of Molecular and Developmental Genetics, Vlaams Instituut voor Biotechnologie, Leuven, Belgium, 4 Center for Human Genetics, KULeuven, Leuven, Belgium, 5 Cardiovascular Developmental Biology Department, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain Abstract Segmentation of the vertebrate body axis is initiated through somitogenesis, whereby epithelial somites bud off in pairs periodically from the rostral end of the unsegmented presomitic mesoderm (PSM). The periodicity of somitogenesis is governed by a molecular oscillator that drives periodic waves of clock gene expression caudo-rostrally through the PSM with a periodicity that matches somite formation. To date the clock genes comprise components of the Notch, Wnt, and FGF pathways. The literature contains controversial reports as to the absolute role(s) of Notch signalling during the process of somite formation. Recent data in the zebrafish have suggested that the only role of Notch signalling is to synchronise clock gene oscillations across the PSM and that somit