numerical analysis of etoposide induced dna breaks数值分析依托泊苷诱导dna断裂.pdfVIP

Numerical Analysis of Etoposide Induced DNA Breaks ´ ¨ Aida Muslimovic, Susanne Nystrom, Yue Gao, Ola Hammarsten* Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden Abstract Background: Etoposide is a cancer drug that induces strand breaks in cellular DNA by inhibiting topoisomerase II (topoII) religation of cleaved DNA molecules. Although DNA cleavage by topoisomerase II always produces topoisomerase II-linked