offsprings leukocyte telomere length, paternal age, and telomere elongation in sperm后代的白细胞端粒长度,父亲的年龄,端粒延长精子.pdfVIP

Offspring’s Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm 1 2 2 3 4 1 Masayuki Kimura , Lynn F. Cherkas , Bernet S. Kato , Serkalem Demissie , Jacob B. Hjelmborg , Michael Brimacombe , 3 2 1 1 1 1 Adrienne Cupples , Janice L. Hunkin , Jefferey P. Gardner , Xiaobin Lu , Xiaojian Cao , Malinee Sastrasinh , 5 6 4 7 2 1* Michael A. Province , Steven C. Hunt , Kaare Christensen , Daniel Levy , Tim D. Spector , Abraham Aviv 1 The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jeresey, United States of America, 2 Twin Research and Genetic Epidemiology Unit, St. Thomas’ Hospital Campus, Kings College London, London, United Kingdom, 3 Boston University School of Public Health, Department of Biostatistics, Boston, Massachusetts, United States of America, 4 The Institute of Public Health, Epidemiology and Statistics, University of Southern Denmark, Odense, Denmark, 5 Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America, 6 Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America, 7 The National Heart, Lung, and Blood Institute’s Framingham Heart Study, Boston, Massachusetts, United States of America Leukocyte telomere length (LTL) is a complex genetic trait. It shortens with age and is associated with a host of aging- related disorders. Recent studies have obse