role of antimicrobial selective pressure and secondary factors on antimicrobial resistance prevalence in escherichia coli from food-producing animals in japan作用的抗生素选择压力和次要因素对抗菌素耐药性流行在日本产肉动物的大肠杆菌.pdfVIP

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2010, Article ID 180682, 12 pages doi:10.1155/2010/180682 Review Article Role of Antimicrobial Selective Pressure and Secondary Factors on Antimicrobial Resistance Prevalence in Escherichia coli from Food-Producing Animals in Japan Kazuki Harada1, 2 and Tetsuo Asai1 1 National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan 2 Department of Veterinary Microbiology, Nippon Veterinary and Life Science University, 1-7-1 Kyonan, Musashino, Tokyo 180-8602, Japan Correspondence should be addressed to Tetsuo Asai, asai-t@nval.maff.go.jp Received 8 December 2009; Accepted 16 March 2010 Academic Editor: John E. Degener Copyright © 2010 K. Harada and T. Asai. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The use of antimicrobial agents in the veterinary field affects the emergence, prevalence, and dissemination of antimicrobial resistance in bacteria isolated from food-producing animals. To control the emergence, prevalence, and dissemination of antimicrobial resistance, it is necessary to implement appropriate actions based on scientific evidence. In Japan, the Japanese Veterinary Antimicrobial Resistance Monitoring System (JVARM) was established in 1999 to monitor the antimicrobial susceptibility of foodborne and commensal bacteria from food-producing animals. The JVARM showed that the emergence and prevalence of resistant Escherichia coli were likely linked t