role of bone morphogenetic proteins-7 (bmp-7) in the renal improvement effect of danggui (angelica sinensis) in type-1 diabetic rats骨形成作用proteins-7(bmp-7)肾功能的改善效果danggui(当归)1型糖尿病大鼠.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 796723, 9 pages doi:10.1155/2011/796723 Original Article Role of Bone Morphogenetic Proteins-7 (BMP-7) in the Renal Improvement Effect of DangGui (Angelica sinensis ) in Type-1 Diabetic Rats Ching-Hua Yeh,1, 2, 3 Chen-Kuei Chang,4 Kai-Chun Cheng,5 Ying-Xiao Li,6 Ying Wen Zhang,6 and Juei-Tang Cheng1, 2, 3 1 Institute of Medical Science, College of Health Science, Chang Jung Christian University, Kway Jen, Tainan 71101, Taiwan 2 Institute of Basic Medical Sciences and Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City 70101, Taiwan 3 Department of Medical Research, Chi Mei Medical Center, Yung Kang City, Tainan Shan 71004, Taiwan 4 Department of Surgery, Mackay Memorial Hospital, Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei City 10107, Taiwan 5 Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima City, Japan 6 Department of Chinese with Western Medicine, Zhongnan Hospitial, Wuhan University, Wuhan 430071, China Correspondence should be addressed to Juei-Tang Cheng, jtcheng@.tw Received 23 January 2009; Accepted 1 October 2009 Copyright © 2011 Ching-Hua Yeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Hyperglycemia induced reactive oxygen species (ROS) generation is believed as major factors leading to diabetic nephropathy (DN). DangGui (Angelica sinensis )