role of gender, smoking profile, hypertension, and diabetes on saphenous vein and internal mammary artery endothelial relaxation in patients with coronary artery bypass grafting角色性别、吸烟,高血压,糖尿病隐静脉和内乳动脉内皮放松在冠状动脉旁路移植患者.pdfVIP

Resea RCh papeR ReseaRCh papeR Oxidative Medicine and Cellular Longevity 3:3, 199-205; May/June 2010; © 2010 Landes Bioscience Role of gender, smoking profile, hypertension, and diabetes on saphenous vein and internal mammary artery endothelial relaxation in patients with coronary artery bypass grafting 1 1 2, andrew Duncan Muir, pascal patrick McKeown and Ulvi Bayraktutan * 1Department of Medicine; Institute of Clinical science; Queen’s University Belfast; Belfast, UK; 2 Division of stroke Medicine; Clinical sciences Building; University of Nottingham; Nottingham City hospital Campus; Nottingham, UK Key words: endothelial dys/function, coronary artery bypass grafting, internal mammary artery, saphenous vein, risk factors Abbreviations: CABG, coronary artery bypass grafting; IMA, internal mammary artery; O2.-, superoxide; NO, nitric oxide; ROS, reactive oxygen species; SV, saphenous vein The aim of this study was to investigate if there was a link between the relaxant responses in saphenous vein (sV) and internal mammary artery (IMa) segments obtained from patients undergoing coronary artery bypass grafting and the patients’ cardiovascular risk factors. endothelium-(in)dependent relaxations were assessed by isometric tension studies. endothelium-dependent relaxant responses were greater in IMa than sV and gender, smoking profile and history of hypertension but not diabetes a