role of heme and heme-proteins in trypanosomatid essential metabolic pathways血红素的作用和heme-proteins trypanosomatid重要的代谢途径.pdfVIP

SAGE-Hindawi Access to Research Enzyme Research Volume 2011, Article ID 873230, 12 pages doi:10.4061/2011/873230 Review Article Role of Heme and Heme-Proteins in Trypanosomatid Essential Metabolic Pathways ´ Karina E. J. Tripodi, Simon M. Menendez Bravo, and Julia A. Cricco Departamento de Quımica Biologica and Instituto de Biologıa Molecular y Celular de Rosario (IBR, CONICET-UNR), ´ ´ ´ Facultad de Ciencias Bioquımicas y Farmaceuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK Rosario, Argentina ´ ´ Correspondence should be addressed to Julia A. Cricco, cricco@.ar Received 21 December 2010; Accepted 7 February 2011 Academic Editor: Claudio Alejandro Pereira Copyright © 2011 Karina E. J. Tripodi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Around the world, trypanosomatids are known for being etiological agents of several highly disabling and often fatal diseases like Chagas disease (Trypanosoma cruzi), leishmaniasis (Leishmania spp.), and African trypanosomiasis (Trypanosoma brucei). Throughout their life cycle, they must cope with diverse environmental conditions, and the mechanisms involved in these processes are crucial for their survival. In this review, we describe the role of heme in several essential metabolic pathways of these protozoans. Notwithstanding trypanosomatids lack of the complete heme biosynthetic pathway, we focus our discussion in the metabolic role played for important heme-proteins, like cytochro