role of peroxisome proliferator-activated receptor alpha in the control of cyclooxygenase 2 and vascular endothelial growth factor involvement in tumor growth控制角色的过氧物酶体proliferator-activated受体α的环氧酶2和血管内皮生长因子参与肿瘤的生长.pdfVIP

Hindawi Publishing Corporation PPAR Research Volume 2008, Article ID 352437, 10 pages doi:10.1155/2008/352437 Review Article Role of Peroxisome Proliferator-Activated Receptor Alpha in the Control of Cyclooxygenase 2 and Vascular Endothelial Growth Factor: Involvement in Tumor Growth ´ ˜ ˜ Raquel Grau, Manuel D. Dıaz-Munoz, Cristina Cacheiro-Llaguno, Manuel Fresno, and Miguel A. Iniguez Departamento de Biologıa Molecular, Centro de Biologıa Molecular “Severo Ochoa” UAM-CSIC, ´ ´ Universidad Autonoma de Madrid, 28049 Madrid, Spain ´ ˜ Correspondence should be addressed to Miguel A. Iniguez, mainiguez@cbm.uam.es Received 11 March 2008; Revised 20 June 2008; Accepted 24 June 2008 Recommended by Dipak Panigrahy A growing body of evidence indicates that PPAR (peroxisome proliferator-activated receptor) α agonists might have therapeutic usefulness in antitumoral therapy by decreasing abnormal cell growth, and reducing tumoral angiogenesis. Most of the anti- inflammatory and antineoplastic properties of PPAR ligands are due to their inhibitory effects on transcription of a variety of genes involved in inflammation, cell growth and angiogenesis. Cyclooxygenase (COX)-2 and vascular endothelial growth factor (VEGF) are crucial agents in inflammatory and angiogenic processes. They also have been significantly associated to cell proliferation, tumor growth, and metastasis, promoting tumor-associated angiogenesis. Aberrant expression of VEGF and COX-2 has been observed in a variety of tumors, poi