role of ppar and its agonist in renal diseasesppar及其受体激动剂在肾脏疾病中的作用.pdfVIP

Hindawi Publishing Corporation PPAR Research Volume 2010, Article ID 345098, 6 pages doi:10.1155/2010/345098 Review Article Role of PPARα and Its Agonist in Renal Diseases Ching-Feng Cheng,1, 2 Hsi-Hsien Chen,3 and Heng Lin4 1 Department of Medical Research, Tzu Chi General Hospital and Department of Pediatrics, Tzu Chi University, Hualien 970, Taiwan 2 Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan 3 Graduate Institute of Clinical Medicine, Taipei Medical University and Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan 4 Graduate Institute of Pharmacology and Toxicology, Tzu Chi University, 701 Chung Yang Road, Section 3, Hualien 970, Taiwan Correspondence should be addressed to Heng Lin, linheng@.tw Received 17 June 2010; Accepted 17 October 2010 ´ Academic Editor: Beatrice Desvergne Copyright © 2010 Ching-Feng Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Peroxisome proliferator-activated receptor (PPAR)-α, a member of a large nuclear receptor superfamily, plays a major role in the regulation of lipid metabolism. Recently, PPARα activation has been shown to confer additional benefits on endothelial function, kidney function, and anti-inflammation, suggesting that PPARα agonists may be good candidates for treating acute renal failure. In clinical application, PPAR-α activators, such as hypolipidemic drugs in fibric acid class, were proven to have therapeutic effects on metabolic syndrome and cardiovascular disease. This paper focuses on signaling pathways, ligand selectiv