role of ppars in radiation-induced brain injuryppars在放射性脑损伤的作用.pdfVIP

Hindawi Publishing Corporation PPAR Research Volume 2010, Article ID 234975, 12 pages doi:10.1155/2010/234975 Review Article Role of PPARs in Radiation-Induced Brain Injury Sriram Ramanan,1, 2 Weiling Zhao,2, 3 David R. Riddle,2, 4 and Mike E. Robbins2, 3 1 Department of Cancer Biology, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA 2 Brain Tumor Center of Excellence, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA 3 Department of Radiation Oncology, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA 4 Department of Neurobiology and Anatomy, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA Correspondence should be addressed to Mike E. Robbins, mrobbins@ Received 19 May 2009; Accepted 15 July 2009 Academic Editor: Christine Linard Copyright © 2010 Sriram Ramanan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Whole-brain irradiation (WBI) represents the primary mode of treatment for brain metastases; about 200 000 patients receive WBI each year in the USA. Up to 50% of adult and 100% of pediatric brain cancer patients who survive 6 months post-WBI will suffer from a progressive, cognitive impairment. At present, there are no proven long-term treatments or preventive strategies for this significant radiation-induced late effect. Recent studies suggest that the pathogenesis of radiation-induced brain injury involves WBI-mediated incr