role of ppar in the control of torpor through fgf21-npy pathway from circadian clock to seasonal change in mammals通过fgf21-npy ppar在麻木的控制通路在哺乳动物生物钟的季节性变化.pdfVIP

Hindawi Publishing Corporation PPAR Research Volume 2009, Article ID 412949, 5 pages doi:10.1155/2009/412949 Review Article Role of PPARα in the Control of Torpor through FGF21-NPY Pathway: From Circadian Clock to Seasonal Change in Mammals Norio Ishida1, 2 1 Clock Cell Biology, Department of Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST), 6-5 Tsukuba Center, 1-1 Higashi, Tsukuba, 305-8566, Japan 2 Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8502, Japan Correspondence should be addressed to Norio Ishida, n.ishida@aist.go.jp Received 18 December 2008; Revised 3 March 2009; Accepted 2 April 2009 Recommended by Richard P. Phipps In nature, hibernating animals encounter fasting, cold temperature and short day seasonally. Torpor is a state of decreased physiological activity in an animal, usually characterized by a reduced body temperature and rate of metabolism to adapt such a severe environment. Ablation of the central clock synchronizer, the suprachiasmatic nucleus in brain, abolishes torpor, a hibernation-like state, implicating the circadian clock involved in this seasonal change. Biologists knows well the energy source of daily heterotherms/hibernators changed from glucose to lipids in winter. Here we review several lines of evidence of a master transcriptional regulator in lipid catabolism, PPARα, in the control of torpor through FGF21-NPY pathway. This indicate the importance of circadian—and photoperiod—regulation of PPARα to tell seasons in our body. Copyright © 2009 Norio Ishida. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distr