serial assessment of cardiac function during and following mitoxantrone infusion in 30 consecutive patients with multiple sclerosis串行的评估心脏功能期间和在30米托蒽醌灌注后连续多发性硬化症患者.pdfVIP

Hindawi Publishing Corporation Multiple Sclerosis International Volume 2010, Article ID 351045, 4 pages doi:10.1155/2010/351045 Clinical Study Serial Assessment of Cardiac Function during and following Mitoxantrone Infusion in 30 Consecutive Patients with Multiple Sclerosis Damian Franzen,1 Angelika Haus,2 and Martin Hellmich3 1 Berrenratherstr. 296, 50937 Koln, Germany ¨ 2 Durenerstr. 332, 50935 Koln, Germany ¨ 3 Institute of Medical Statistics and Epidemiology, University of Cologne, 50924 Koln, Germany ¨ Correspondence should be addressed to Damian Franzen, info@damianfranzen.de Received 4 April 2010; Revised 1 September 2010; Accepted 20 October 2010 Academic Editor: Bruno Brochet Copyright © 2010 Damian Franzen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Immunosuppressive therapy is an established therapeutic option in patients suffering from multiple sclerosis (MS). In an open nonrandomized study we serially assessed cardiac function in 30 consecutive patients with MS before, during, and after mitoxantrone therapy. Mitoxantrone (12 mg/m2 ) was administered intravenously at 3-month intervals. Before each infusion, cardiac function was assessed by history taking, resting electrocardiogram, and echocardiography. Whereas no patient experienced clinical signs of heart failure, left ventricular pump function decreased continuously during mitoxantrone therapy and did not recover after cessation. The presented data suggest a dose-dependent an