reversion of p-glycoprotein-mediated multidrug resistance in human leukemic cell line by diallyl trisulfide降级p-glycoprotein-mediated的多药耐药性在人类白血病细胞系由己二烯三硫化物.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 719805, 11 pages doi:10.1155/2012/719805 Research Article Reversion of P-Glycoprotein-Mediated Multidrug Resistance in Human Leukemic Cell Line by Diallyl Trisulfide Qing Xia,1 Zhi-Yong Wang,2 Hui-Qing Li,3 Yu-Tao Diao,3 Xiao-Li Li,4 Jia Cui,5 Xue-Liang Chen,1 and Hao Li1 1 Department of Hematology, Qilu Hospital, Shandong University, Shandong, Jinan 250012, China 2 Department of Emergency, Qilu Hospital, Shandong University, Shandong, Jinan 250012, China 3 Institute of Basic Medicine, Shandong Academy of Medical Sciences, Shandong, Jinan 250062, China 4 Soochow University and Department of Hematology, Branch Guangci of First Affi liated Hospital, Jiangsu, Suzhou 215128, China 5 Shouguang Centre for Disease Control and Prevention, Shouguang 262700, China Correspondence should be addressed to Xue-Liang Chen, xlchen1999@163.com and Hao Li, haoli611@ Received 15 February 2012; Accepted 16 May 2012 Academic Editor: Vincenzo De Feo Copyright © 2012 Qing Xia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Multidrug resistance (MDR) is the major obstacle in chemotherapy, which involves multiple signaling pathways. Diallyl trisulfide (DATS) is the main sulfuric compound in garlic. In the present study, we aimed to explore whether DATS could overcome P- glycoprotein-(P-gp-)mediated MDR in K562/A02 cells, and to investigate whether NF-κB suppression is involved in DATS-induced reversal of MDR. MTT assay revealed that cotreatment with DATS increased the response of K562/A02 cells to adriamycin (the