retrospective case-control study of apolipoprotein jclusterin protein expression in early liveborn neonatal deaths with and without pontosubicular necrosis载脂蛋白的回顾性病例对照研究jclusterin蛋白表达在早期活胎产的新生儿死亡,没有pontosubicular坏死.pdfVIP

Hindawi Publishing Corporation Pathology Research International Volume 2012, Article ID 479359, 6 pages doi:10.1155/2012/479359 Clinical Study Retrospective Case-Control Study of Apolipoprotein J/Clusterin Protein Expression in Early Liveborn Neonatal Deaths with and without Pontosubicular Necrosis Kathreena M. Kurian1 and Declan McGuone2 1 Department of Neuropathology, Frenchay Hospital, Frenchay Park Road, Frenchay, Bristol BS16 1LE, UK 2 Department of Neuropathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA Correspondence should be addressed to Kathreena M. Kurian, kathreena.kurian@.uk Received 14 February 2012; Accepted 23 March 2012 Academic Editor: Marco Volante Copyright © 2012 K. M. Kurian and D. McGuone. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Aims . Our objective was to examine Apo J protein expression in a total of 27 early liveborn neonatal deaths (less than 7 days of age) selected from the Scottish Perinatal Study (gestation of 25–42 weeks) comparing a group with histological pontosubicular necrosis (PSN) (n = 12) to a control group lacking PSN (n = 15). Methods. Using immunohistochemistry we evaluated postmortem pons and hippocampus from patients with PSN versus controls. Results. In the group with PSN, 11/12 (92%) cases showed positive Apo J neurones in the hippocampus/pons compared with 6/15 (40%) cases without PSN (P = 0.014, odds ratio 27.5, 95% confidence interval 2.881–262.48, using exact logistic regression)—independent of gestation, presence or absence of clinical asphyxia, duration of labour, or postnatal age. Clinical asphyxia