serotonin receptor 2ac is involved in electroacupuncture inhibition of pain in an osteoarthritis rat model5 -羟色胺受体2 ac参与电针刺激抑制疼痛的骨关节炎大鼠模型.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 619650, 6 pages doi:10.1093/ecam/neq016 Original Article Serotonin Receptor 2A/C Is Involved in Electroacupuncture Inhibition of Pain in an Osteoarthritis Rat Model Aihui Li,1 Yu Zhang,2 Lixing Lao,1 Jiajia Xin,1 Ke Ren,3 Brian M. Berman,1 and Rui-Xin Zhang1 1 Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA 2 Department of Neurobiology, Shanxi Medical University, Taiyuan 030001, Shanxi, PR, China 3 Department of Neural and Pain Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA Correspondence should be addressed to Rui-Xin Zhang, rzhan001@ Received 16 September 2009; Accepted 8 February 2010 Copyright © 2011 Aihui Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Osteoarthritis currently has no cure. Acupuncture can benefit patients with knee osteoarthritis by providing pain relief, improving joint function and serving as an effective complement to standard care. However, the underlying mechanisms of its effects are still not completely understood. The present study, an investigation of the effectiveness and mechanisms of electroacupuncture (EA) in attenuating osteoarthritis pain in a rat model, is focused on the involvement of 5-hydroxytryptamine 2A/C (5-HT2A/C) receptors, which play an important role in pain modulation at the spinal level. Osteoarthritis was induced under isoflurane anesthesia by a single intraarticular injection of monosodium iodoacetate (3 mg/50 μL/rat) into one hind leg of each rat. EA was given at acupoints