review pancreatic -cell neogenesis revisited检查胰腺细胞新生再现.pdfVIP

Experimental Diab. Res., 5:111–121, 2004 c Copyright Taylor and Francis Inc. ISSN: 1543-8600 print / 1543-8619 online DOI: 10.1080/15438600490455079 Review: Pancreatic β-Cell Neogenesis Revisited Maryline Paris, C´ecile Tourrel-Cuzin, C´edric Plachot, and Alain Ktorza Laboratoire de Physiopathologie de la Nutrition, Universite Paris 7, Paris, France intra-islet precursors also have been proposed and subpop- β-cell neogenesis triggers the generation of new β-cells ulations of cell precursors inside islets have been described from precursor cells. Neogenesis from duct epithelium is the by some authors. Nestin positive cells, which have been con- most currently described and the best documented process sidered as the main candidates, appear rather as progeni- of differentiation of precursor cells into β-cells. It is con- tors of endothelial cells rather than β-cells and contribute to tributes not only to β-cell mass expansion during fetal and angiogenesis rather than neogenesis. To take advantage of nonatal life but it is also involved in the maintenance of the the different differentiation processes may be a direction for β-cell mass in adults. It is also required for the increase in future cellular therapies. Ultimately, a better understanding β-cell mass in situations of increase insulin demand (obesity, of the molecular mechanisms involved in β-cell neogenesis pregnancy). A large number of factors controlling the dif- will allow us to use any type of differentiated and/or undif- ferentiation of β-cells has been identified. They are classified ferentiated cells as a source of potential cell precursors. into the following main categories: growth factors, cytokine and infla