review of the history and current status of cell-transplant approaches for the management of neuropathic pain回顾历史和现状的细胞移植的方法神经性疼痛的管理.pdfVIP

Hindawi Publishing Corporation Pain Research and Treatment Volume 2012, Article ID 263972, 22 pages doi:10.1155/2012/263972 Review Article Review of the History and Current Status of Cell-Transplant Approaches for the Management of Neuropathic Pain 1 2 3 ¨ 1, 4 Mary J. Eaton, Yerko Berrocal, Stacey Q. Wolfe, and Eva Widerstrom-Noga 1 Miami VA Health System Center, D806C, 1201 NW 16th Street, Miami, FL 33125, USA 2 Department of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA 3 Department of Neurosurgery, Tripler Army Medical Center, 1 Jarrett White Road, Honolulu, HI 96859, USA 4 The Miami Project to Cure Paralysis, Miller School of Medicine at the University of Miami, Miami, FL 33136, USA Correspondence should be addressed to Mary J. Eaton, meatonscience@ Received 8 March 2012; Accepted 9 April 2012 Academic Editor: Steve McGaraughty Copyright © 2012 Mary J. Eaton et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Treatment of sensory neuropathies, whether inherited or caused by trauma, the progress of diabetes, or other disease states, are among the most difficult problems in modern clinical practice. Cell therapy to release antinociceptive agents near the injured spinal cord would be the logical next step in the development of treatment modalities. But few clinical trials, especially for chronic pain, have tested the transplant of cells or a cell line to treat human disease. The history of t